Abstract
Ophirapstanol trisulfate [1], a new steroid trisulfate related to sokotrasterol trisulfate was isolated from a deep water marine sponge Topsentia ophiraphidites. Compound 1 exhibited significant inhibition in the guanosine diphosphate/G-protein RAS exchange assay. The structure elucidation of 1 and ophirapstanol [2] by nmr spectroscopy is described.
MeSH terms
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Animals
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Circular Dichroism
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Genes, ras / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Mutagenicity Tests
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Mutagens / isolation & purification*
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Mutagens / toxicity
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Porifera / chemistry*
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Sterols / isolation & purification*
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Sterols / toxicity
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Sulfuric Acid Esters / isolation & purification*
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Sulfuric Acid Esters / toxicity
Substances
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Mutagens
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Sterols
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Sulfuric Acid Esters
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ophirapstanol trisulfate